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股骨頭壞死治療現(xiàn)狀

2022-09-16
蓮池小骨
閱讀次數(shù):0

股骨頭無菌性壞死的保守治療方法,主要是由Ficat等前人推薦的股骨頸髓芯減壓。由于其治療結(jié)果不一致,后又優(yōu)化為帶血管游離腓骨移植,或往股骨頭壞死區(qū)注射自體干細胞。法國的倡導者發(fā)表了長期治療結(jié)果,顯示在股骨頭壞死早期治療有效,而且股骨頭仍保持圓形。

但近十年來,在沒有倡導者的報告中,在對照研究中、有時在隨機研究中,對單純髓芯減壓提出了反對意見。確認了在壞死區(qū)域再生、和穩(wěn)定的可能性。但這些技術不易運用。細胞治療技術需要對骨髓組織進行離心、得到富集血液細胞的小球。已經(jīng)證明該技術長期有效性和安全性,應用于年輕的、影像正常、MRI診斷股骨頭壞死的患者。但很多股骨頭軟骨分離、股骨頭塌陷的患者,除了全髖關節(jié)置換,沒有更好的選擇。

人工關節(jié)置換技術可靠,應用氧化鋁陶瓷,隨訪20年以上,未發(fā)現(xiàn)磨損和骨溶解。雖然對這些年輕和活動量大的患者,存在關節(jié)不穩(wěn)、假體周圍骨折等并發(fā)癥。

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圖1 該患者39歲,花園體力勞動者,因雙髖疼痛求診,發(fā)現(xiàn)雙側(cè)股骨頭壞死、左股骨頭塌陷。左側(cè)進行全髖關節(jié)置換,無癥狀的右髖注射了干細胞。術后1年X線片顯示,右股骨頭保持圓形。

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圖2 同一患者術后一年雙髖核磁,無并發(fā)癥

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圖3 術后三年,右側(cè)股骨頭輕度塌陷

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圖4 同一患者術后3年,核磁顯示右股骨頭壞死軟骨分離。患者尚未回歸工作,坐姿活動無疼痛;跑步或某天劇烈運動后感受到右腹股溝中度疼痛。他對置換一側(cè)的結(jié)果很滿意,想急于做右側(cè)手術,以便早日恢復職業(yè)工作。


原文導讀

Treatments ofavascular osteonecrosis of the hip:Current treatments

Conservativetreatments for aseptic osteonecrosis of the femoral head have their ancestor inthe core decompression of the femoral neck, recommended by Ficat. Due toinconsistent results, this treatment has been optimized by either vascularizedfibular grafting, or by injecting autologous stem cells into the necrotic zone.The French promoters have published long-term results, showing efficacy in theearly stages of the disease, where the femoral head has not yet lost itssphericity. Over the last 10years, comparative studies, sometimes randomized,opposing them to simple core decompression, have been published bynon-promoters, confirming the possibility of stabilization or even regressionof necrosis area. But these techniques are not easy to implement. Cell therapyrequires treatment of marrow samples by centrifugation to obtain a pellet witha high concentration of haematopoietic cells. The now proven long-term efficacyas well as the safety of this technique make it the method of choice fortreating young patients detected at the sub-radiological stage by MRI.Unfortunately, many are seen late with detached cephalic cartilage or collapsedfemoral head and have no other option than total hip arthroplasty. Thistechnique is very reliable. With alumina ceramics, results of more than 20yearsshow the absence of wear and osteolysis, although other complications such asinstability or periprosthetic fractures may occur in these young and activepatients.

文獻出處:Massin P.Treatments of avascular osteonecrosis of the hip: Current treatments. Morphologie. 2021 Jun; 105(349): 120-126. doi: 10.1016/j.morpho.2020.06.003. Epub2020 Jul 8. PMID: 32653168.

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來源:304關節(jié)學術

譯者:羅殿中

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